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DeCS
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Descriptor English:
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Aprotinin
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Descriptor Spanish:
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Aprotinina
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Descriptor Portuguese:
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Aprotinina
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Synonyms English:
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Basic Pancreatic Trypsin Inhibitor
Bovine Kunitz Pancreatic Trypsin Inhibitor
Kunitz Pancreatic Trypsin Inhibitor
Trypsin Inhibitor, Kunitz, Pancreatic
Kallikrein-Trypsin Inactivator
BPTI, Basic Pancreatic Trypsin Inhibitor
Trypsin Inhibitor, Basic, Pancreatic
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Tree Number:
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D12.776.083
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Definition English:
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A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995) |
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Pharmacological Action:
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Hemostatics
Serine Proteinase Inhibitors
Trypsin Inhibitors
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History Note English:
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90; was KALLIKREIN-TRYPSIN INACTIVATOR 1966-89
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Allowable Qualifiers English:
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Record Number:
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28294
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Unique Identifier:
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D007611
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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